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It is no wonder that now the latest idea is to blend prescription medications in the hopes that while using the combination can have the miraculous results which they so desperately want and perhaps need. Using two separate drugs to shed pounds can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err along the side of caution and allow the FDA do its job and demand some study be done so your public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say everything to keep people on the medications. Researchers found that participants taking this drug for a year, dropped a few pounds within a month and have kept the body weight off during the entire 56 weeks from the study. Contrave is often a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that by right now there aren't long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure levels and heart rate, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver after that uptake through the intestines and possesses no therapeutic effect. Buprenorphine will be the active substance; it can be absorbed beneath the tongue (and through the mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who may have had gastric bypass, where the first part of the intestine is bypassed and the stomach contents empty into a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the location where the drug is taken up with the duodenum and transferred directly to the liver with the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken on by portions of the intestine that are not served with the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.